Wissenschaftliche Publikationen von Mitarbeitern

Originalarbeiten und systematische Reviews

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Alper BS, Oettgen P, Kunnamo I, Iorio A, Ansari MT, Murad MH, Meerpohl JJ, Qaseem A, Hultcrantz M, Schunemann HJ, Guyatt G: Defining certainty of net benefit: a GRADE concept paper. BMJ Open, 2019;9(6):e027445.

Al Said S, Alabed S, Kaier K, Tan AR, Bode C, Meerpohl JJ, Duerschmied D. Non-vitamin K antagonist oral anticoagulants (NOACs) post-percutaneous coronary intervention: a network meta-analysis. The Cochrane database of systematic reviews. 2019;12(12):CD013252-CD.

Barbaresko J, Neuenschwander M, Schwingshackl L, Schlesinger S: Dietary factors and diabetes-related health outcomes in patients with type 2 diabetes: protocol for a systematic review and meta-analysis of prospective observational studies. BMJ Open. 2019;9(7):e027298.

Binder N, Blümle A, Balmford J, Motschall E, Oeller P, Schumacher M: Bias in relative risk analyses when disease information is missing due to death: Prevalence and relevance in epidemiological and aging cohort studies. J Clin Epidemiol, 2019; 105:68-79.

Braun C, McRobert CJ: Conservative management following closed reduction of traumatic anterior dislocation of the shoulder. Cochrane Database of Systematic Reviews, 2019; Issue 5: Art. No.: CD004962

Brefka S, Dallmeier D, Muhlbauer V, von Arnim CAF, Bollig C, Onder G, Petrovic M, Schonfeldt-Lecuona C, Seibert M, Torbahn G, Voigt-Radloff S, Haefeli WE, Bauer JM, Denkinger MD: A Proposal for the Retrospective Identification and Categorization of Older People With Functional Impairments in Scientific Studies-Recommendations of the Medication and Quality of Life in Frail Older Persons (MedQoL) Research Group. J Am Med Dir Assoc, 2019; 20(2):138-146.

Conrad S, Kaiser L, Kallenbach M, Meerpohl JJ, Morche J: [GRADE: Evidence to Decision (EtD) frameworks - a systematic and transparent approach to making well informed healthcare choices. 2: Clinical guidelines]. Z Evid Fortbild Qual Gesundhwes. 2019; [Epub ahead of print].

Dietrich S, Jacobs S, Zheng JS, Meidtner K, Schwingshackl L, Schulze MB. Gene-lifestyle interaction on risk of type 2 diabetes: A systematic review. Obesity reviews: an official journal of the International Association for the Study of Obesity. 2019;20(11):1557-71.

Eapen M, Brazauskas R, Walters MC, Bernaudin F, Bo-Subait K, Fitzhugh CD, Hankins JS,Kanter J, Meerpohl JJ, Bolaños-Meade J, Panepinto JA, Rondelli D, Shenoy S, Williamson J, Woolford, TL, Gluckman, E, Wagner, JE, Tisdale, JF. Effect of donor type and conditioning regimen intensity on allogeneic transplantation outcomes in patients with sickle cell disease: a retrospective multicentre, cohort study. Lancet Haematol. 2019;6(11):e585-e96.

Eykelenboom M, van Stralen MM, Olthof MR, Schoonmade LJ, Steenhuis IHM, Renders CM, PEN Consortium: Political and public acceptability of a sugar-sweetened beverages tax: a mixed-method systematic review and meta-analysis. The international journal of behavioral nutrition and physical activity. 2019;16(1):78.

Frank F, Bjerregaard F, Bengel J, Bitzer EM, Heimbach B, Kaier K, Kiekert J, Kramer L, Kricheldorff C, Laubner K, Maun A, Metzner G, Niebling W, Salm C, Schutter S, Seufert J, Farin E, Voigt-Radloff S. Local, collaborative, stepped and personalised care management for older people with chronic diseases (LoChro): study protocol of a randomised comparative effectiveness trial. BMC geriatrics. 2019;19(1):64.

Gaforio JJ, Visioli F, Alarcon-de-la-Lastra C, Castaner O, Delgado-Rodriguez M, Fito M, Hernández AF, Huertas JR, Martinez-González MA, Menéndez JA, Osada J, Papadaki A, Parron T, Pereira JE, Rosillo MA, Sánchez-Quesada C, Schwingshackl L, Toledo E, Tsatsakis AM. Virgin Olive Oil and Health: Summary of the III International Conference on Virgin Olive Oil and Health Consensus Report, JAEN (Spain) 2018. Nutrients. 2019;11(9).

Gonzalez-González AI, Schmucker C, Nothacker J, Motschall E, Nguyen TS, Brueckle M-S, Blom J, van den Akker M, Röttger K, Wegwarth O, Hoffmann T, Straus SE, Gerlach FM, Meerpohl JJ, Muth C. Health-related preferences of older patients with multimorbidity: an evidence map. BMJ open. 2019;9(12):e034485-e.

González-González AI, Schmucker C, Blom J, van den Akker M, Nguyen TS, Nothacker J, Meerpohl JJ, Röttger K, Wegwarth O, Hoffmann T, Straus S E, Gerlach F M, Muth Ch: Health-related preferences of older patients with multimorbidity: the protocol for an evidence map. BMJ Open. 2019;9:e029724.

Hardt J, Meerpohl JJ, Metzendorf MI, Kienle P, Post S, Herrle F: Lateral pararectal versus transrectal stoma placement for prevention of parastomal herniation. Cochrane Database of Systematic Reviews, 2019;Issue 4: Art.No.:CD009487.

Huhn M, Nikolakopoulou A, Schneider-Thoma J, Krause M, Samara M, Peter N, Arndt Th, Bäckers L, Rothe Ph, Cipriani A, Davis J, Salanti G, Leucht S: Comparative efficacy and tolerability of 32 oral antipsychotics for the acute treatment of adults with multi-episode schizophrenia: a systematic review and network meta-analysis. The Lancet. 2019. [epub ahead of print].

Johnston BC, Zeraatkar D, Han MA, Vernooij RWM, Valli C, El Dib R, Marshall C, Stover PJ, Fairweather-Taitt S, Wojcik G, Bhatia F, de Souza R, Brotons C, Meerpohl JJ, Patel CJ, Djulbegovic B, Alonso-Coello P, Bala MM, Guyatt GH. Unprocessed Red Meat and Processed Meat Consumption: Dietary Guideline Recommendations From the Nutritional Recommendations (NutriRECS) Consortium. Ann Intern Med. 2019. [Epub ahead of print]

Krause M, Gutsmiedl K, Bighelli I, Schneider-Thoma J, Chaimani A, Leucht S: Efficacy and tolerability of pharmacological and non-pharmacological interventions in older patients with major depressive disorder: A systematic review, pairwise and network meta-analysis. European Neuropsychopharmacology. 2019. [epub ahead of print].

Krnic Martinic M, Meerpohl JJ, von Elm E, Herrle F, Marusic A, Puljak L. Attitudes of editors of core clinical journals about whether systematic reviews are original research: a mixed-methods study. BMJ Open. 2019;9(8):e029704.

Kullenberg de Gaudry D, Lohner S, Schmucker C, Kapp P, Motschall E, Horrlein S, Roger C, Meerpohl JJ: Milk A1 beta-casein and health-related outcomes in humans: a systematic review. Nutrition reviews. 2019. [Epub ahead of print].

Labonté V, Alsaid D, Lang B, Meerpohl JJ. Psychological and social consequences of non-invasive prenatal testing (NIPT): a scoping review. BMC Pregnancy Childbirth. 2019;19(1):385.

Labonté V, Sirsch EG, Thiesemann R, Möhler R: Algorithm‐based pain management for people with dementia in nursing homes - protocol. Cochrane Database of Systematic Reviews, 2019; Issue 5: Art. No.: CD013339.

Lohler J, Walther LE, Hansen F, Kapp P, Meerpohl JJ, Wollenberg B, Schonweiler R, Schmucker C: The prevalence of hearing loss and use of hearing aids among adults in Germany: a systematic review. European archives of oto-rhino-laryngology: official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS): affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2019. [Epub ahead of print].

Morgan RL, Thayer KA, Santesso N, Holloway AC, Blain R, Eftim SE, Goldstone AE, Ross P, Ansari M, Akl E, Filippini T, Hansell A, Meerpohl JJ, Mustafa RA, Verbeek J, Vinceti M, Whaley P, Schünemann HJ, GRADE Working Group: A risk of bias instrument for non-randomized studies of exposures: A users' guide to its application in the context of GRADE. Environment international, 2019; 122:168-184.

Morze J, Schwedhelm C, Bencic A, Hoffmann G, Boeing H, Przybylowicz K, Schwingshackl L: Chocolate and risk of chronic disease: a systematic review and dose-response meta-analysis. European journal of nutrition, 2019; [Epub ahead of print].

Muhlbauer V, Dallmeier D, Brefka S, Bollig C, Voigt-Radloff S, Denkinger M: The Pharmacological Treatment of Arterial Hypertension in Frail, Older Patients-a Systematic Review. Dtsch Arztebl Int. 2019;116(3):23-30.

Murad MH, Liem RI, Lang ES, Akl EA, Meerpohl JJ, DeBaun MR, Tisdale JF, Brandow AM, Lanzkron SM, Chou ST, Webb S, Mustafa RA. 2019 sickle cell disease guidelines by the American Society of Hematology: methodology, challenges, and innovations. Blood advances. 2019;3(23):3945-50.

Neuenschwander M, Ballon A, Weber KS, Norat T, Aune D, Schwingshackl L, Schlesinger S: Role of diet in type 2 diabetes incidence: umbrella review of meta-analyses of prospective observational studies. BMJ. 2019;366:l2368.

Neuenschwander M, Hoffmann G, Schwingshackl L, Schlesinger S: Impact of different dietary approaches on blood lipid control in patients with type 2 diabetes mellitus: a systematic review and network meta-analysis. Eur J Epidemiol. 2019. [Epub ahead of print].

Nicol JU, Rohwer A, Young T, Bavuma CM, Meerpohl JJ: Correction to: Integrated models of care for diabetes and hypertension in low- and middle-income countries (LMICs): Protocol for a systematic review. Syst Rev. 2019;8(1):36.

Nußbaumer-Streit B, Teufer B, Langer G, Meerpohl JJ, Ebenberger A, Gartlehner G. GRADE equity guidelines 2: Considering health equity in GRADE guideline development - equity extension of the guideline development checklist. Zeitschrift fur Evidenz, Fortbildung und Qualitat im Gesundheitswesen. 2019;147-148:120-6. [Epub 19.11.2019]

Pai M, Yeung CHT, Akl EA, Darzi A, Hillis C, Legault K, Meerpohl JJ, Santesso N, Taruscio D, Verhovsek M, Schünemann HJ, Iorio A: Strategies for eliciting and synthesizing evidence for guidelines in rare diseases. BMC Med Res Methodol. 2019;19(1):67.

Piggott T, Morgan RL, Cuello-Garcia CA, Santesso N, Mustafa RA, Meerpohl JJ, Schünemann HJ. GRADE notes: Extremely Serious, GRADE’s Terminology for Rating Down by 3-Levels. Journal of Clinical Epidemiology. 2019. [Epub ahead of print]

Rzewuska M, Charani E, Clarkson JE, Davey PG, Duncan EM, Francis JJ, Gillies K, Kern WV, Lorencatto F, Marwick CA, MCEwen J, Moehler R, Morris AM, Ramsay CR, Rogers van Katwyk S, Skodvin B, Smith I, Suh KN, Grimshaw JM: Prioritizing research areas for antibiotic stewardship programmes in hospitals: a behavioural perspective consensus paper. Clin Microbiol Infect, 2019; 25(2):163-168.

Saemann L, Schmucker C, Rösner L, Beyersdorf F, Benk C: Perfusion parameters and target values during extracorporeal cardiopulmonary resuscitation: a scoping review protocol. BMJ Open. 2019;9(8):e030562.

Sanchez A, Thomas C, Deeken F, Wagner S, Kloppel S, Kentischer F, von Arnim CAF, Denkinger M, Conzelmann LO, Biermann-Stallwitz J, Joos S, Sturm H, Metz B, Auer R, Skrobik Y, Eschweiler GW, Rapp MA; PAWEL Study group (Metzger F, Straub A, Krüger T, Bausenhart F, Renz P, Walther A, Bruns C, Spank J, Sabbah P, Häusler A, Förstner B, Schulze S, Maurer C, Martin M, Heimbach B, Voigt-Radloff S, Reichel H, Liebold A, Küster O, Brefka S, Kirschner S, Stober N, Mehlhorn U, Wasem J, Neumann A). Patient safety, cost-effectiveness, and quality of life: reduction of delirium risk and postoperative cognitive dysfunction after elective procedures in older adults-study protocol for a stepped-wedge cluster randomized trial (PAWEL Study). Trials. 2019;20(1):71.

Santesso N, Glenton C, Dahm P, Garner P, Akl EA, Alper B, Brignardello-Petersen R,Carrasco-Labra A, De Beer H, Hultcrantz M, Kuijpers T, Meerpohl JJ, Morgan R, Mustafa R, Skoetz N, Sultan S, Wiysonge C, Guyatt G, Schünemann HJ, Grade Working Group. GRADE guidelines 26: informative statements to communicate the findings of systematic reviews of interventions. Journal of clinical epidemiology. 2019:S0895-4356(19)30416-0. [Epub ahead of print]

Schlesinger S, Schwingshackl L, Neuenschwander M, Barbaresko J: A critical reflection on the grading of the certainty of evidence in umbrella reviews. Eur J Epidemiol. 2019. [Epub ahead of print].

Schmidt BM, Durao S, Toews I, Bavuma CM, Meerpohl JJ, Kredo T: Screening strategies for hypertension: a systematic review protocol. BMJ Open. 2019;9(1):e025043.

Schmucker C, Kapp P, Motschall E, Loehler J, Meerpohl JJ: Prevalence of hearing loss and use of hearing aids among children and adolescents in Germany: a systematic review. BMC Public Health. 2019;19(1):1277.

Schneider-Thoma J, Efthimiou O, Bighelli I, Dörries C, Huhn M, Krause M, Reichelt L, Röder H, Furukawa T A, Davis J M, Leucht S: Second-generation antipsychotic drugs and short-term somatic serious adverse events: a systematic review and meta-analysis. The Lancet Psychiatry. 2019. [Epub ahead of print].

Schünemann HJ, Cuello C, Akl EA, Mustafa RA, Meerpohl JJ, Thayer K, Morgan RL, Gartlehner G, Kunz R, Katikreddi SV, Sterne J, Higgins JP, Guyatt G: GRADE Guidelines: 18. How ROBINS-I and other tools to assess risk of bias in non-randomized studies should be used to rate the certainty of a body of evidence. J Clin Epidemiol. 2019;111:105-14.

Schünemann HJ, Zhang Y, Oxman AD, Expert Evidence in Guidelines Group: Distinguishing opinion from evidence in guidelines. BMJ. 2019;366:l4606.

Schwedhelm C, Iqbal K, Schwingshackl L, Agogo GO, Boeing H, Knuppel S: Meal analysis for understanding eating behavior: meal- and participant-specific predictors for the variance in energy and macronutrient intake. Nutrition journal, 2019;18(1):15.

Schwedhelm C, Schwingshackl L, Agogo GO, Sonestedt E, Boeing H, Knuppel S: Associations of food groups and cardiometabolic and inflammatory biomarkers - does the meal matter? Br J Nutr. 2019:1-19. [Epub ahead of print].

Schwingshackl L, Neuenschwander M, Hoffmann G, Buyken AE, Schlesinger S. Dietary sugars and cardiometabolic risk factors: a network meta-analysis on isocaloric substitution interventions. Am J Clin Nutr. 2019. [Epub ahead of print]

Schwingshackl L, Knuppel S, Michels N, Schwedhelm C, Hoffmann G, Iqbal K, de Henauw S, Boeing H, Devleesschauwer B: Intake of 12 food groups and disability-adjusted life years from coronary heart disease, stroke, type 2 diabetes, and colorectal cancer in 16 European countries. Eur J Epidemiol, 2019. [Epub ahead of print].

Schwingshackl L, Krause M, Schmucker C, Hoffmann G, Rucker G, Meerpohl JJ. Impact of different types of olive oil on cardiovascular risk factors: A systematic review and network meta-analysis. Nutrition, metabolism, and cardiovascular diseases: NMCD. 2019;29(10):1030-9.

Schwingshackl L, Morze J, Hoffmann G: Mediterranean diet and health status: active ingredients and pharmacological mechanisms. British journal of pharmacology. 2019. [Epub ahead of print].

Schwingshackl L, Schwarzer G, Rucker G, Meerpohl JJ: Perspective: Network Meta-analysis Reaches Nutrition Research: Current Status, Scientific Concepts, and Future Directions. Advances in nutrition, 2019. [Epub ahead of print].

Skoetz N, Goldkuhle M, Weigl A, Dwan K, Labonté V, Dahm P, Meerpohl JJ, Djulbegovic B, van Dalen EC: Methodological review showed correct absolute effect size estimates for time-to-event outcomes in less than one-third of cancer-related systematic reviews. J Clin Epidemiol, 2019; 108:1-9.

Toews I, Lohner S, Küllenberg de Gaudry D, Sommer H, Meerpohl JJ: Association between intake of non-sugar sweeteners and health outcomes: systematic review and meta-analyses of randomised and non-randomised controlled trials and observational studies. BMJ, 2019;364:k4718.

Voigt-Radloff S, Schöpf AC, Boeker M, Frank L, Farin E, Kaier K, Körner M, Wollmann K, Lang B, Meerpohl JJ, Möhler R, Niebling W, Serong J, Lange R, van der Keylen P, Maun A: Well informed physician-patient communication in consultations on back pain – study protocol of the cluster randomized GAP trial. BMC Family Practice, 2019; 20(1):33.

Walther LE, Löhler J, Agrawal Y, Motschall E, Schubach F, Meerpohl JJ, Schmucker C: Evaluating the Diagnostic Accuracy of the Head-Impulse Test: A Scoping Review. JAMA otolaryngology-- head & neck surgery. 2019; [Epub ahead of print].

Wieschowski S, Riedel N, Wollmann K, Kahrass H, Muller-Ohlraun S, Schurmann C, Kelley S, Kszuk U, Siegerink B, Dirnagl U, Meerpohl JJ, Strech D: Results dissemination from clinical trials conducted at German university medical centres was delayed and incomplete. J Clin Epidemiol, 2019;115:37-45.


Alonso-Coello P, Oxman AD, Moberg J, Brignardello-Petersen R, Akl EA, Davoli M, Treweek S, Mustafa RA, Vandvik PO, Meerpohl JJ, Guyatt GH, Schünemann HJ; el GRADE Working Group: [GRADE Evidence to Decision (EtD) frameworks: a systematic and transparent approach to making well informed healthcare choices. 2: Clinical practice guidelines]. Gac Sanit, 2018; 32(2):167.e1-167.e10.

Bollig C, Nothacker M, Lehane C, Motschall E, Lang B, Meerpohl JJ, Schmucker C: Prophylactic antibiotics before cord clamping in cesarean delivery: a systematic review. Acta obstetricia et gynecologica Scandinavica, 2018; 97(5):521-535.

Booth A, Lewin S, Glenton C, Munthe-Kaas H, Toews I, Noyes J, Rashidian A, Berg RC, Nyakang'o B, Meerpohl JJ, GRADE-CERQual Coordinating Team: Applying GRADE-CERQual to qualitative evidence synthesis findings-paper 7: understanding the potential impacts of dissemination bias. Implement Sci, 2018; 13(Suppl 1):12.

Dechartres A, Atal I, Riveros C, Meerpohl JJ, Ravaud P: Association Between Publication Characteristics and Treatment Effect Estimates: A Meta-epidemiologic Study.  Ann Intern Med, 2018; 169(6):385-393.

Greenaway C, Makarenko I, Chakra CNA, Alabdulkarim B, Christensen R, Palayew A, Tran A, Staub L, Pareek M, Meerpohl JJ, Noori T, Veldhuijzen I, Pottie K, Castelli F, Morton RL: The Effectiveness and Cost-Effectiveness of Hepatitis C Screening for Migrants in the EU/EEA: A Systematic Review. Int J Environ Res Public Health, 2018; 15(9).

Lederer A, Schmucker C, Kousoulas L, Fichner-Feigl S, Huber R: Naturopathic treatment and complementary medicine in surgical practice—a systematic review. Dtsch Arztebl Int, 2018; 115(49):815-21.

Legault K, Schunemann H, Hillis C, Yeung C, Akl EA, Carrier M, Cervera R, Crowther M, Dentali F, Erkan D, Espinosa G, Khamashta M, Meerpohl JJ, Moffat K, O'Brien S, Pengo V, Rand JH, Rodriguez Pinto I, Thom L, Iorio A: McMaster RARE-Bestpractices clinical practice guideline on diagnosis and management of the catastrophic antiphospholipid syndrome. J Thromb Haemost, 2018; 16:1656-1664.

Meyer G, Mohler R, Kopke S: Reducing waste in evaluation studies on fall risk assessment tools for older people. J Clin Epidemiol, 2018; 102:139-143.

Möhler R, Renom A, Renom H, Meyer G: Personally tailored activities for improving psychosocial outcomes for people with dementia in long-term care. Cochrane Database of Systematic Reviews, 2018; Issue 2: Art. No.: CD009812.

Monagle P, Cuello CA, Augustine C, Bonduel M, Brandao LR, Capman T, Chan AKC, Hanson S, Male C, Meerpohl JJ, Newall F, O´Brien SH, Raffini L, van Ommen H, Wiernikowski J, Williams S, Bhatt M, Riva JJ, Roldan Y, Schwab N, Mustafa RA, Vesely SK: American Society of Hematology 2018 Guidelines for management of venous thromboembolism: treatment of pediatric venous thromboembolism. Blood advances, 2018; 2(22):3292-316.

Nussbaumer-Streit B, Grillich L, Glechner A, Affengruber L, Gartlehner G, Morche J, Meerpohl JJ: [GRADE: Evidence to Decision (EtD) frameworks - a systematic and transparent approach to making well informed healthcare choices. 1: Introduction]. Z Evid Fortbild Qual Gesundhwes, 2018; 134:57-66.

Pardo-Hernandez H, Urrútia G, Meerpohl JJ, Marušić A, Wager E, Bonfill X: Opinions and potential solutions regarding dissemination bias from funding agencies of biomedical research in Europe. OPEN Project Consortium. Eval Clin Pract, 2018; 24(1):72-79.

Scherer RW, Meerpohl JJ, Pfeifer N, Schmucker C, Schwarzer G, von Elm E: Full publication of results initially presented in abstracts. Cochrane Database of Systematic Reviews, 2018; Issue 11. Art. No.: MR000005.

Schmidt  BM, Durao  S, Toews  I, Bavuma  CM, Meerpohl  JJ, Kredo  T. Screening strategies for hypertension (Protocol). Cochrane Database of Systematic Reviews, 2018; Issue 11. Art. No.: CD013212.

Strech D, Sievers S, Märschenz S, Riedel N, Wieschowski S, Meerpohl JJ, Langhof H, Müller-Ohlraun S, Dirnagl U: Tracking the timely dissemination of clinical studies. Characteristics and impact of 10 tracking variables [version 1; referees: awaiting peer review]. F1000Research. 2018;7(1863).

Takla A, Wiese-Posselt M, Harder T, Meerpohl JJ, Robl-Mathieu M, Terhardt M, van der Sande M, Wichmann O, Zepp F, Klug SJ: Background paper for the recommendation of HPV vaccination for boys in Germany. Bundesgesundheitsblatt, 2018; 61(9): 1170-1186.

Toews I, George AT, Peter JV, Kirubakaran R, Fontes LES, Ezekiel JPB, Meerpohl JJ: Interventions for preventing upper gastrointestinal bleeding in people admitted to intensive care units. Cochrane Database of Systematic Reviews, 2018; Issue 6. Art. No.: CD008687.

Torbahn G, Hofmann H, Rücker G, Bischoff K, Freitag MH, Dersch R, Fingerle V, Motschall E, Meerpohl JJ, Schmucker C: Efficacy and Safety of Antibiotic Therapy in Early Cutaneous Lyme Borreliosis: A Network Meta-analysis. JAMA Dermatol, 2018; 154(11):1292-1303.

Wieschowski S, Riedel N, Wollmann K, Kahrass H, Mueller-Ohlraun S, Schuermann C, Kelley S, Kszuk U, Siegerink B, Dirnagl U, Meerpohl JJ, Strech D: Benchmarking university medical centres for responsible metrics. A cross sectional study on timely results dissemination across 36 German centres. bioRxiv, 2018. Preprint. Now published in Journal of Clinical Epidemiology doi: 10.1016/j.jclinepi.2019.06.002.

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